‘‘Click chemistry’’ has recently been introduced as a new way of categorizing organic reactions that are highly efficient, modular and selective, and occur with simple work-up procedures. The 1,3-dipolar cycloaddition of azides to alkynes has become the most popular click reaction, and is widely used in biology, chemistry and material science. By using the efficient click reaction, different architectures of macromolecules such as dendrimers, dendronized linear polymers, hydrogels, supra-polymers and novel conjugated polymers can be created. Click chemistry strategy has also been implemented for the preparation of segmented copolymers of monomers polymerizable by different mechanisms.